Quinolone Its injection is widely used in clinical prac […]
Its injection is widely used in clinical practice. Among them, quinoline carboxylic acid products are the most. However, most of the quinoline carboxylic acids are unstable to light, prone to photolysis, and the antibacterial activity is lowered. In recent years, the results of photoreaction characteristics of quinolones suggest that photoreaction is an exothermic reaction, which is more likely to occur under solution conditions and aerobic conditions; photoreaction can not only produce degradants, but also product polymerization. The reaction rate is related to the pH of the solution and the structure of the drug itself.
The UV spectra of sparfloxacin, ciprofloxacin, levofloxacin and lomefloxacin in UVA light were measured by HPLC method. The photolysis kinetic parameters T1/2 were determined and the photostabilization in solution was obtained. Sexual order is sparfloxacin, ciprofloxacin, levofloxacin, lomefloxacin. Lomefloxacin hydrochloride injection is easy to be stable to heat, sensitive to light, easy to decompose, and decomposes about 25% at room temperature of 4500Lx for 10 days, and the color gradually deepens. The decomposition rate conforms to the first-order kinetic process, so it is packaged in addition to the factory. Attention should also be paid to avoiding light during transportation, storage and use of drip.
Fluroxacin glucose injection is unstable in light, extremely unstable under strong light, and decomposes in the presence of light. When placed under natural light for 1 h, the color changes to a pale yellow color. It is suggested that the drug must be stored in the dark and it is recommended that when the infusion is used clinically, it should be accompanied by the infusion and protected from light.
By liquid chromatography-mass spectrometry. The photodegradation products of gatifloxacin were analyzed. Combined with liquid chromatogram and mass spectrum, it was found that gatifloxacin not only lost cyclopropyl and carboxyl groups after illumination (the two groups are just gatifloxacin). The group) also produced a fragment ion dimer peak. Therefore, gatifloxacin products should be protected from light during production, storage and dripping to reduce the generation of impurities, minimize the effects of phototoxicity and ensure product quality. Zhou Honghua et al. used liquid-mass spectrometer to separate and identify photodegradation products of gatifloxacin injection. It is concluded that the structure of photodegradation impurities of gatifloxacin injection is 6-fluoro-6-methoxy-7-(3-A 1--1-piperazinyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid; and experimental studies have shown that gatifloxacin injection is stable in the dark.
In addition to the above drugs, hydrocortisone, prednisone, furosemide, reserpine, procaine hydrochloride, baicalein, vitamin A and the like are all light-sensitive drugs.