What are the drugs that are prone to photochemical degradation?(3)


Pyridine drugs For example, nifedipine, nitrendipine, c […]

Pyridine drugs
For example, nifedipine, nitrendipine, cilnidipine, and nimodipine contain structures that are unstable to light. Determination of nifedipine, nitrendipine, and nimodipine in the Chinese Pharmacopoeia (2005 edition) Regarding the substance inspection, the dissolution measurement is required to be protected from light. The photostability test showed that the sinipine was mainly converted into the Z isomer under the light condition, from the amount of the degradation product. The degradation of the solution for 4 h was close to that of solid light for 3 days, indicating that the photosensitivity of cilnidipine was increased in the solution state. Nimodipine injection is a commonly used drug for the treatment of cerebrovascular disease. Orthogonal test on the stability and influencing factors of nimodipine infusion shows that light has the greatest influence on the stability of infusion, followed by infusion type, and finally It is temperature, therefore, it should be protected from light when using nimodipine infusion.