According to the Chinese Pharmacopoeia, the disintegrat […]
According to the Chinese Pharmacopoeia, the disintegration time limit (dissolution) of the capsule should be disintegrated and passed through the sieve within 30 minutes. In the actual experiment, the disintegration time limit of the capsule is generally about 10 minutes. The so-called disintegration time limit is the time for the experimental drug to melt and pass through the instrument for simulating gastric peristalsis. However, drug disintegration (melting) and drug absorption are two concepts, and melting does not mean that it is absorbed.
Because absorption is not the function of the stomach but the function of the small intestine, only the contents of the stomach can be absorbed into the small intestine. It is estimated that the time from the passage of the drug into the stomach to the absorption of the small intestine is about 30 minutes. It takes 2 hours to fully absorb. Because the time for gastric emptying is 2 hours. Therefore, whether it is tablets, capsules, pills (except controlled release, sustained release), as long as the disintegration time limit is acceptable, the time of absorption is almost the same.